The Stillwater campus, established in 2003, serves multiple missions to area students. Primarily a Gateway Program, the Stillwater campus serves students who would otherwise not be admitted to Oklahoma State University. The campus, however, also admits students seeking general education courses that transfer to other comprehensive colleges and universities. Northern Stillwater admits approximately 300 new students each fall and spring semester, serving some 1,700 students.
The Tonkawa campus, established in 1901, serves as the administrative center for Northern with campuses in Tonkawa, Enid, and Stillwater. All program oversight in academic, financial, student service, personnel, development, physical plant, and information technology is housed in Tonkawa. Some, 2,200 students attend class on campus, by ITV, via online, or at technology centers. Offering 70 degrees with an array of courses, Northern distinguishes itself as a leading community college in Oklahoma.
The Enid campus was established in 1999 in conjunction with the Oklahoma State Regents for Higher Education (OSRHE) and the City of Enid. This campus has grown in offering multiple two-year liberal arts degree programs to some 1,200 students each semester. The Enid campus continues to expand its faculty, curriculum, and numerous clubs and activities.